{"data":{"id":2679,"lang":"en","title":"Vitamin B5 Derivative Pantethine Calms Psoriasis-Driving Immune Cells in Mice and a Small Human Trial","summary":"Chinese researchers report that pantethine, a cheap vitamin B5 derivative, dampens overactive dendritic cells and eased psoriasis in mice and in 24 patients.","category":"science","category_label":"Science","published_at":"2026-11-12T19:00:40Z","updated_at":"2026-11-12T19:00:40Z","url":"https://techtools.cz/tools/news/article/2679-vitamin-b5-derivative-pantethine-calms-psoriasis-driving-immune-cells-in-mice","api_url":"https://techtools.cz/news-api/v1/articles/2679?lang=en","markdown_url":"https://techtools.cz/news-api/v1/articles/2679.md?lang=en","image_url":"https://www.news-medical.net/image-handler/picture/2014/6/Psoriasis-620x480.jpg","word_count":126,"reading_time_minutes":1,"sources":[{"url":"https://www.news-medical.net/news/20261027/Vitamin-B5-derivative-pantethine-helps-prevent-and-alleviate-psoriasis-symptoms-in-mice.aspx","domain":"news-medical.net"},{"url":"https://sciencedaily.com/releases/2026/11/261108233057.htm","domain":"sciencedaily.com"},{"url":"https://www.genengnews.com/topics/drug-discovery/vitamin-derivative-pantethine-alleviates-psoriasis-symptoms-in-small-human-trial/","domain":"genengnews.com"}],"translation":{"lang":"cs","id":2753,"title":"Derivát vitaminu B5 pantethin tlumí imunitní buňky způsobující lupénku u myší i v malé studii na lidech","url":"https://techtools.cz/tools/news/clanek/2753-derivat-vitaminu-b5-pantethin-tlumi-imunitni-bunky-zpusobujici-lupenku-u-mysi-i","api_url":"https://techtools.cz/news-api/v1/articles/2753?lang=cs"},"content":"A Chinese team reported in the Journal of Experimental Medicine that pantethine, a vitamin B5 derivative sold as a supplement, dampens dendritic cells, the immune cells that drive psoriasis. In patients, elevated Vanin enzymes break pantethine down, which raises cholesterol production in these cells and overactivates them.\n\nBlocking Vanins prevented psoriasis-like disease in mice, and pantethine reduced inflammation in the animals. In a small proof-of-concept trial of 24 patients, those who took pantethine tablets alongside topical treatment improved more over 12 weeks than the control group, especially patients with high cholesterol.\n\nThe trial is tiny and preliminary, and the authors call for larger studies before pantethine could be considered a treatment. It matters because it points to a cholesterol-linked mechanism and a low-cost add-on to explore."}}