# CRISPR Therapy Cuts Bad Cholesterol in Half for a Full Year, Trial Finds

*2026-09-28 10:01 UTC · Science · 1 min read*

> A single CRISPR gene-editing infusion cut LDL cholesterol by over half for a year in a first-in-human trial, with no serious side effects.

Cleveland Clinic cardiologist Luke Laffin led a first-in-human Phase 1 trial testing CTX310, an experimental CRISPR-Cas9 gene-editing therapy from CRISPR Therapeutics, in patients with lipid disorders that had not responded to standard medication.

A single one-time infusion of CTX310 switches off the ANGPTL3 gene in the liver. Among the 15 participants, those who received the highest dose showed a 52.5% reduction in LDL cholesterol and a 47.8% drop in triglycerides after 12 months, with no serious adverse events reported during follow-up.

The results, presented at the European Society of Cardiology's 2026 congress and published in the New England Journal of Medicine, suggest a single treatment could replace a lifetime of daily cholesterol-lowering pills for people with hard-to-treat lipid disorders linked to heart attacks and stroke. Researchers plan to monitor participants for 15 years to confirm the therapy's long-term safety.

## Sources

- [newsroom.clevelandclinic.org](https://newsroom.clevelandclinic.org/2026/08/28/cleveland-clinic-first-in-human-trial-of-crispr-gene-editing-therapy-shown-to-safely-and-continuously-lower-cholesterol-and-triglycerides-after-one-year)
- [sciencedaily.com](https://www.sciencedaily.com/releases/2026/09/260925005434.htm)

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TechTools News · https://techtools.cz/tools/news/article/2454-crispr-therapy-cuts-bad-cholesterol-in-half-for-a-full-year-trial-finds
Česká verze: https://techtools.cz/tools/news/clanek/2528-terapie-crispr-snizila-spatny-cholesterol-o-polovinu-na-cely-rok-ukazuje-studie