{"data":{"id":2300,"lang":"en","title":"Obesity Leaves a Molecular \"Memory\" in Immune Cells for Years After Weight Loss","summary":"A 10-year study finds obesity leaves DNA-methylation \"memory\" marks in immune T cells that can linger 5-10 years after weight loss, helping explain why disease risk stays elevated.","category":"science","category_label":"Science","published_at":"2026-09-02T14:01:53Z","updated_at":"2026-09-02T14:01:53Z","url":"https://techtools.cz/tools/news/article/2300-obesity-leaves-a-molecular-memory-in-immune-cells-for-years-after-weight-loss","api_url":"https://techtools.cz/news-api/v1/articles/2300?lang=en","markdown_url":"https://techtools.cz/news-api/v1/articles/2300.md?lang=en","image_url":"https://www.sciencedaily.com/images/1920/heart-disease-in-obesity-anatomy-crop.webp","word_count":190,"reading_time_minutes":1,"sources":[{"url":"https://www.birmingham.ac.uk/news/2026/obesity-leaves-a-lasting-memory-in-immune-cells","domain":"birmingham.ac.uk"},{"url":"https://www.sciencedaily.com/releases/2026/08/260830000013.htm","domain":"sciencedaily.com"}],"translation":{"lang":"cs","id":2373,"title":"Obezita zanechává v imunitních buňkách molekulární „paměť“ i roky po zhubnutí","url":"https://techtools.cz/tools/news/clanek/2373-obezita-zanechava-v-imunitnich-bunkach-molekularni-pamet-i-roky-po-zhubnuti","api_url":"https://techtools.cz/news-api/v1/articles/2373?lang=cs"},"content":"A 10-year study led by the University of Birmingham has found that obesity leaves a lasting molecular \"memory\" in the body's helper T cells (CD4+ lymphocytes) that can persist for 5 to 10 years after a person loses weight. The imprint is written through DNA methylation — chemical tags that alter gene activity without changing the DNA sequence itself — affecting pathways that control cellular waste removal (autophagy) and immune-system aging (senescence).\n\nLed by Professor Claudio Mauro, with Dr. Belinda Nedjai (Queen Mary University London) and Professor Andy Hogan (Maynooth University Ireland), the team analyzed immune cells across four groups: patients on weight-loss injections, people with early-onset obesity from Alstrom Syndrome, participants in a 10-week exercise program, and surgery patients with and without obesity, plus mouse models on high-fat diets.\n\nThe findings, published September 1 in EMBO Reports, help explain a long-standing clinical puzzle: why people who successfully lose weight often remain at elevated risk of type 2 diabetes, cardiovascular disease and certain cancers. Researchers say sustained weight management over several years should gradually fade the \"obesity memory,\" but short-term weight loss alone may not be enough to reset that immune risk."}}