{"data":{"id":1818,"lang":"en","title":"Stanford Scientists Regrow Lost Cartilage and Reverse Arthritis in Major Breakthrough","summary":"Stanford scientists blocked an aging protein to regrow knee cartilage in mice and human tissue, raising hopes for a drug-based alternative to joint replacement surgery.","category":"science","category_label":"Science","published_at":"2026-06-12T18:02:36Z","updated_at":"2026-06-12T18:02:36Z","url":"https://techtools.cz/tools/news/article/1818-stanford-scientists-regrow-lost-cartilage-and-reverse-arthritis-in-major","api_url":"https://techtools.cz/news-api/v1/articles/1818?lang=en","markdown_url":"https://techtools.cz/news-api/v1/articles/1818.md?lang=en","image_url":"https://www.sciencedaily.com/images/1920/3d-knee-joint-inflammation-osteoarthritis.webp","word_count":148,"reading_time_minutes":1,"sources":[{"url":"https://www.sciencedaily.com/releases/2026/06/260612021604.htm","domain":"sciencedaily.com"},{"url":"https://www.sciencealert.com/breakthrough-to-restore-aging-joints-could-help-treat-osteoarthritis","domain":"sciencealert.com"}],"translation":{"lang":"cs","id":1891,"title":"Vědci ze Stanfordu obnovili chrupavku a zvrátili artritidu v průlomovém výzkumu","url":"https://techtools.cz/tools/news/clanek/1891-vedci-ze-stanfordu-obnovili-chrupavku-a-zvratili-artritidu-v-prulomovem-vyzkumu","api_url":"https://techtools.cz/news-api/v1/articles/1891?lang=cs"},"content":"Stanford researchers have discovered a way to regenerate worn-out joint cartilage by blocking a protein called 15-PGDH, which plays a key role in cellular aging. In older mice, the treatment restored lost knee cartilage and prevented arthritis from developing after serious joint injuries — without relying on stem cells.\n\nThe mechanism works by coaxing existing cartilage-producing cells, called chondrocytes, to revert their gene activity to a more youthful state. Crucially, when human cartilage samples collected during knee replacement surgeries were exposed to the treatment, they began producing new, functional cartilage — a promising sign for eventual human applications.\n\nOsteoarthritis affects approximately one in five U.S. adults and costs roughly $65 billion annually in direct healthcare. An oral version of the 15-PGDH inhibitor is already in clinical trials for age-related muscle weakness, and researchers plan to extend trials to cartilage regeneration soon. The study was published in Science in June 2026."}}