# Texas A&M Nasal Spray Reverses Brain Aging in Mice After Just Two Doses, Restoring Memory and Calming Inflammation

*2026-05-26 18:01 UTC · Science · 1 min read*

> Texas A&M researchers reversed brain aging in mice with a stem-cell-derived nasal spray, restoring memory and cutting inflammation after just two doses.

Researchers at Texas A&M led by Dr. Ashok Shetty have developed a nasal spray that reversed signs of brain aging in mice, restoring memory and quieting chronic inflammation after just two doses. The spray delivers extracellular vesicles (EVs) derived from human neural stem cells, which carry microRNAs straight to the brain through the nose without invasive procedures.

The team targeted neuroinflammaging, the slow chronic inflammation that builds with age and drives cognitive decline. The microRNAs suppress the NLRP3 inflammasome and cGAS-STING signalling pathways, which are known to fuel aging-related brain inflammation. Treated mice, aged 18 months (roughly a 60-year-old human), showed reduced inflammation markers, restored mitochondrial function and better memory, with benefits appearing within weeks and lasting months. The effect held in both sexes.

The study, backed by the National Institute on Aging, was published in the Journal of Extracellular Vesicles. The findings are early and animal-only, so safety, dosing and human effectiveness still need to be confirmed before any clinical use.

## Sources

- [scitechdaily.com](https://scitechdaily.com/scientists-reverse-brain-aging-with-simple-nasal-spray/)
- [stories.tamu.edu](https://stories.tamu.edu/news/2026/04/14/scientists-reverse-brain-aging-with-a-nasal-spray/)
- [neurosciencenews.com](https://neurosciencenews.com/nasal-spray-reverse-brain-aging-30519/)

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TechTools News · https://techtools.cz/tools/news/article/1718-texas-a-m-nasal-spray-reverses-brain-aging-in-mice-after-just-two-doses
Česká verze: https://techtools.cz/tools/news/clanek/1791-nosni-sprej-z-texas-a-m-zvratil-starnuti-mozku-u-mysi-uz-po-dvou-davkach